Our genome composed of DNA defines most of our attributes. A common analogy is a software code that determines the outcome of a computer program (e.g. this website).  Errors in this genetic code (mutations) can then cause disorders that can affect people throughout their life. Genetic disorders such as sickle cell disease and cystic fibrosis are life-limiting. Can we correct or replace erroneous genes to treat such disorders? But how do we find these mutations within our genome that contains >6 billion DNA base pairs (analogous to letters) and correct them precisely? 

Naturally occurring CRISPR/Cas9 nucleases from bacteria can be used to find target sequences in the genome with great precision and correct disease causing mutations. Our lab is currently focused on developing genetic therapies using CRISPR/Cas9 technology to treat cystic fibrosis.  Once perfected, the tools can be leveraged to engineer novel functions into cells to treat other disorders. Learn more here

Are you interested in genome editing and want to join our team?

We are recruiting members at the undergraduate, post-baccalaureate, graduate and postdoctoral levels

Please contact vaidyanathan.32@osu.edu